Delfi Detects What Others Cannot
We are creating next-generation liquid biopsies fueled by breakthroughs in genomics and machine learning to revolutionize early cancer detection.
Unlocking a Vast Trove of Diagnostic Data
Our unique, genome-wide fragmentomic-based approach to early detection isn’t limited to the small number of mutations or alterations detected by other liquid biopsies, which are just pieces of a much larger picture.
Higher Performance Than Other Methods
By examining cell-free DNA fragments across the genome, Delfi’s machine learning system analyzes orders of magnitude more data on the presence or absence of cancer than possible with conventional technologies that look for limited changes in DNA sequences, methylation, or proteins. Delfi’s highly accurate assays are not affected by confounding conditions such as clonal hematopoiesis of indeterminate potential (CHIP) or other diseases.
A Growing Body of Evidence
First published in Nature in 2019, Delfi’s methods continue to demonstrate the potential of using this technology to develop high-performing, accessible liquid biopsy tests.
Our research and scientific findings in respected peer-reviewed publications and events
Single-molecule genome-wide mutation profiles of cell-free DNA for non-invasive detection of cancer
Bruhm, D.C., Mathios, D., Foda, Z.H. et al. Nature Genetics. 10.1038 – s41588-023-01446-3 (2023)
Cell-free DNA fragmentomes in the diagnostic evaluation of patients with symptoms suggestive of lung cancer
Leal, A., Mathios, D., Jakubowski, D., et al. Chest. 10.1016 – 2023.04.033 (2023)
Detecting liver cancer using cell-free DNA fragmentomes. Foda Z., Annapragada A., Boyapati, K., et al. Cancer Discovery. CD-22-0659 (2022).
Detection and characterization of lung cancer using cell-free DNA fragmentomes. Mathios, D., Johansen, J.S., Cristiano, S. et al. Nat Commun. 12, 5060 (2021).
White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer.
Leal A, van Grieken NCT, Palsgrove DN, et al.
Nat Commun. 2020;11(1):525.
Genome-wide cell-free DNA fragmentation in patients with cancer. Cristiano S, Leal A, Phallen J, et al. Nature. 2019;570(7761):385-389.
Cell-free DNA fragmentation profiling for monitoring therapeutic response in metastatic colorectal cancer. Alipanahi B, van ‘t Erve I, Lumbard K, et al. Presented at AACR Meeting: April 14-19, 2023.
Prospective evaluation of cell-free DNA fragmentomes for lung cancer detection. Mazzone P, Wong K, Tsay J, et al. Presented at AACR Meeting: April 14-19, 2023.
CASCADE-LUNG: Validation of a blood-based assay that evaluates cell-free DNA fragmentation patterns to detect lung cancer. Barta J, Freedland S, Mazzone P et al. Presented at AACR Meeting: April 14-19, 2023.
DELFI as a Real-Time Treatment Response Assessment for Patients with Cancer. Presented at AACR Meeting Online: April 8-13, 2022.
Genome-wide cfDNA fragmentation in patients with cancer and other diseases. Carey J, Jones S, Leal A, et al. Presented at 2021 ASCO Annual Meeting Online: June 4–8, 2021.
Modeling cell-free DNA fragment size densities for non-invasive detection of cancer. Carey J, Chesnick B, Butler D, Rongione M, Parmigiani G, Velculescu VE, Dracopoli NC, Scharpf RB. Presented at 2021 ASCO Annual Meeting Online: June 4–8, 2021.
Detecting cancer using genome wide cfDNA fragmentation in a prospective diagnostic cohort.
Carey J, Leal A, Chesnick B, et al. Presented at
Virtual AACR Annual Meeting Week 1: April 10-15, 2021.
FRAGMENTOMICS studies the physical properties of circulating cell-free DNA fragments. DNA is packaged abnormally in cancer cells, resulting in abnormal fragment patterns when cancer cells die and release their DNA into the bloodstream. Cell-free DNA fragments in the blood can indicate the presence of cancer and suggest its likely location in the body.